|Awarded On||February 21, 2019|
|Title||Role of Long Noncoding RNAs in Breast Cancer: Identification, Characterization, and Determination of Molecular Functions|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||W. Lee Kraus|
Breast cancer is the second leading cause of cancer-related mortality in women, with a 1 in 8 lifetime of risk for women in the United States. A key hurdle in developing better treatments for breast cancers is a lack of understanding at the molecular level of what promotes the growth of breast cancer cells, and why some breast cancers grow in response to estrogens, while others do not. In this regard, we are studying a relatively new and uncharacterized class of molecules called long non-coding RNAs (lncRNAs). In work during the previous round of funding of this grant, we discovered a lncRNA expressed in estrogen-responsive “luminal” breast cancers, which codes for a short polypeptide c...