Grant ID RP190132
Awarded On February 21, 2019
Title Multiomic Biomarker Discovery for Therapy-Related Neurocognitive Impairment in Childhood Acute Lymphoblastic Leukemia
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Austin L Brown
Cancer Sites Leukemia
Contracted Amount $1,187,006
Lay Summary

Therapeutic improvements have resulted in long-term survival rates exceeding 90% of children diagnosed with acute lymphoblastic leukemia, the most common childhood cancer. As the population of patients who survive beyond their initial diagnosis continues to grow, improving the quality of life for these survivors becomes increasingly important. Unfortunately, many survivors of childhood leukemia suffer from adverse treatment-related neurocognitive impairment. Prevention of such impairment could result in improvements in daily functioning, academic performance, and quality of life for survivors of childhood leukemia. Although neurocognitive impairment is a well-established consequence of moder...

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