|Awarded On||August 24, 2018|
|Title||Molecular Targeted Magnetic Resonance Reporter for Cancer Detection|
|Award Mechanism||High Impact/High Risk|
|Principal Investigator/Program Director||Daniel Carson|
Colorectal cancer (CRC) is the 2nd leading cause of cancer-related deaths in Texas. Early diagnosis is central to cancer care. Often only tumors greater than 5mm can be imaged using existing technologies, limiting the ability of early diagnosis. Our proposed constructs, "MR Reporters,” will significantly increase the sensitivity of detecting cancer by utilizing several amplification steps and combining the versatile binding affinity of antibodies with the sensitivity of hyperpolarized Magnetic Resonance (MR). Antibodies have high-affinity and specificity to their protein targets and several are approved for cancer treatment. MR Reporters utilize antibody based molecular targeting and le...