Grant ID RP180848
Awarded On August 24, 2018
Title Autoimmune-Prone Mouse Models for Studying Immune-Related Adverse Events Associated With Cancer Immunotherapy
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Nan Yan
Cancer Sites All Sites
Contracted Amount $200,000
Lay Summary

Recent advance in cancer immunotherapy has demonstrated exciting potential. These drugs that are known as immune checkpoint inhibitors (or ICIs) remove breaks from immune cells and unleash maximum power to attack tumors. Despite tremendous successes with this approach in controlling tumor growth, these unleashed immune cells also attack normal organs resulting in conditions known as immune-related adverse events (or irAEs). The incidence of irAE is reported to range from 15-60% in single drug clinical trails, with even higher occurrence and more severe outcome in combination therapy. irAE affects multiple organs, and in severe cases becoming irreversible and fatal. Poor understanding of irAE...

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