|Awarded On||August 24, 2018|
|Title||Polymer Nanodiscs: Novel Lipoprotein-Mimicking Nanocarriers With High Stability and Long Circulation Time for Enhanced Anticancer Drug Delivery|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Tech University Health Sciences Center|
|Principal Investigator/Program Director||Hongjun Liang|
|Cancer Sites||All Sites|
Because most anticancer drugs are highly toxic and dissolve poorly in water, their controlled delivery across aqueous physiological pathways with desirable dosage and specificity to tumor cells is an extraordinary challenge that remains largely unsolved. Nanotechnology has been widely anticipated to benefit cancer therapy because a unique character of tumors is their “leaky” vessels, i.e. cancer cells are poorly aligned to create nanoscopic pores (one nanometer is one ten thousandth of the width of a typical human hair). As such, drug-loaded nanocarriers with the right sizes accumulate preferentially at the tumor sites. Despite decades of active efforts, translational progress is still few a...