|Awarded On||August 24, 2018|
|Title||Integrative Analysis of Structural Variants in Cancer Genomes|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jian Xu|
Acute myeloid leukemia (AML) accounts for 90% of all acute leukemias in adults and 15-20% of those in children. AML is a genetically heterogeneous blood cancer and its disease development is associated with a variety of genomic structural variants (SVs) such as chromosomal translocations, large sequence insertions and deletions. The discovery of recurrent AML-associated SVs has provided successful targets for diagnosis, prognosis and therapeutics; however, due to major limitations of conventional SV detection tools, recurrent SVs were not identified or characterized in the majority of AML cases. This represents a major challenge in risk stratification and clinical management of these patient...