|Awarded On||August 24, 2018|
|Title||Metabolic Enablers of Melanoma Progression|
|Award Mechanism||Multi-Investigator Research Awards (Version 2)|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Sean Morrison|
Melanoma is responsible for over 80% of deaths from skin cancer and the incidence of melanoma is increasing over time. A number of effective new therapies for melanoma have been introduced into common use in recent years but most people diagnosed with stage IV disease still die of their disease. New therapies are required. Stage IV melanoma arises when melanoma cells metastasize (move around the body) to distant sites. After “distant metastasis”, disease is systemic: it can no longer be cured by surgery and it is much more likely to be resistant to other therapies. If we could prevent distant metastasis we could reduce the fraction of patients that progress to stage IV disease and cure rate...