|Awarded On||August 24, 2018|
|Title||Preclinical Radiation Core Facility (PCRCF)|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Michael D Story|
|Cancer Sites||All Sites|
More than 50% of cancer patients are treated by radiation therapy with curative intent. Pre-clinical radiation research performed using cell or small animal models, is important for understanding radiobiological mechanisms and developing new radiotherapeutic strategies that combine immunotherapy or targeted agents, as examples. Unfortunately, and a concern of the federal health agencies, is the fact that many investigators do not have the proper foundation in physics and radiobiology to properly use this technology. Experimental devices are often improperly calibrated and radiation doses are poorly calculated. Errors of >20% are often observed, which is in stark contrast to human RT where...