|Awarded On||August 24, 2018|
|Title||The Early-Life Exposome and Risk of Pediatric Acute Lymphoblastic Leukemia|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Philip Lupo|
Each year in the United States (U.S.), more than 15,000 children and adolescents younger than 21 years of age are diagnosed with cancer, which is the leading cause of morbidity and mortality in youth. Over 10% of these cases are diagnosed in Texas. Pediatric cancer incidence has steadily increased by an annual average of 0.6% since 1975, with acute lymphoblastic leukemia (ALL) accounting for the largest proportion of cases (23%). This steady increase suggests that pollutants in the environment may be playing a significant role in pediatric ALL risk. However, we do not understand why most children are diagnosed with ALL. Being exposed to environmental pollutants (e.g., heavy metals like arsen...