Grant ID RP180751
Awarded On August 24, 2018
Title Methods for Assessment and Quantification of Imperfect dsDNA Break Repair
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Zbyszek Otwinowski
Cancer Sites Breast, Ovary, Prostate
Contracted Amount $200,000
Lay Summary

Defective DNA repair may be inherited and so could be present in every cell of the body. Alternatively, it may appear at some point during tumorigenesis and thus be restricted to only a subset of cells. In both cases, such defects will result in elevated mutation levels. These mutations will follow patterns which are shaped by the specific DNA repair pathway that has been affected, the stage of tumorigenesis, and also by tissue-specific and environmental factors. There is an ongoing effort to identify and classify a category of these mutations known as clonal mutations, which are amplified in specific tissues, for instance by cancer growth. However, current sequencing methods are not sensiti...

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