|Awarded On||August 24, 2018|
|Title||Noninvasive Diagnostic Imaging of Brain Cancer Using Hyperpolarized 13C-Labeled L-Tryptophan and L-Methionine|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas at Dallas|
|Principal Investigator/Program Director||Lloyd Lumata|
|Cancer Sites||Brain and Other Nervous System|
Glioblastoma multiforme (GBM) is a highly aggressive and mostly chemoresistant form of brain cancer with very dismal chance of survival. Early and diagnostically accurate detection of glioblastoma is thus of the utmost importance. Recent studies revealed that GBMs have a particular high addiction to consume two essential amino acids, methionine and tryptophan. This study proposes to capitalize on this GBM addiction by turning the abnormal metabolism of these two key amino acids in GBM into its diagnostic Achilles’ heel using hyperpolarization technology. Hyperpolarization can enhance the magnetic resonance imaging (MRI) signals of biomolecules such as the amino acids by >10,000-fold. Sinc...