Grant ID RP180553
Awarded On February 21, 2018
Title Structural and Functional Characterization of the DNA Double Strand Break Processing Complex of Mre11-Rad50
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Texas Tech University
Principal Investigator/Program Director Michael Latham
Cancer Sites Breast, Colorectal, Prostate
Contracted Amount $459,184
Lay Summary

A hallmark of various forms of cancer is genomic instability caused by DNA damage, which can arise from hereditary or sporadic mutations. To combat the daily onslaught of unwanted DNA modifications, several parallel DNA repair systems have evolved to sense and repair the various lesions that affect our genome. When one of these repair systems goes awry, carcinogenic mutations and rearrangement of the DNA can occur. However, the recent success of new chemotherapies has shown that knocking out a second repair pathway presents a viable option for the fight against cancer (i.e., PARP inhibitors). Thus, it is critical to understand DNA damage repair pathways for both cancer prevention and treatme...

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