|Awarded On||February 21, 2018|
|Title||Circulating Exosomes as Biomarkers for Lung Cancer Early Detection|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Samir Hanash|
|Cancer Sites||Lung and Bronchus|
Lung cancer is the leading cause of cancer death among men, and the second leading cause among women worldwide. Lung cancer screening with low-dose computed tomography (LDCT) has been shown to reduce mortality by 20%, although there are concerns including high false positivity, cost, and radiation exposure. Of note, the false positive rate of lung cancer screening with LDCT alone was 96.4%. Blood-based biomarkers are a promising and attractive approach to complement LDCT. We identified and have undertaken initial validation studies of a set of circulating lung cancer biomarkers, while we have recently developed high-yield and high-purity methods for isolation of circulating exosomes, which h...