Grant ID RP180404
Awarded On February 21, 2018
Title Noninvasive detection of anthracycline induced cardiotoxicity using hyperpolarized carbon 13 based magnetic resonance spectroscopic imaging
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Clinical Translation
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Vlad Zaha
Cancer Sites Breast
Contracted Amount $2,397,204
Lay Summary

More than 20 million cancer survivors will live in The Unites States in 2026 by American Cancer Society estimates. Conventional chemotherapy, such as the anthracycline doxorubicin, results in a more than 15-fold increase in the risk of heart failure in long term cancer survivors. However, the individual sensitivity to anthracycline induced cardiotoxicity cannot be currently predicted. Anthracyclines can damage mitochondria, the subcellular structures that generate energy for heart contraction. This damage results in a deleterious cellular energetic flux imbalance and can activate programmed heart muscle cell death. New technology has been developed that allows to detect these cellular bioche...

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