|Awarded On||February 21, 2018|
|Title||Turn ON the Tumor Contrast in Lymph Node Metastases for Occult Disease Detection|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jinming Gao|
|Cancer Sites||Breast, Head and Neck|
Lymph node metastasis (LNM) is the most important determinant factor for survival for many solid cancers. The gold standard for detection of regional metastatic disease from most cancers is a regional nodal dissection and histologic examination by a trained pathologist. This can result in significant morbidity including shoulder dysfunction and pain in head and neck patients, and lymphedema, pain and impaired arm use in breast cancer patients. Sentinel lymph node biopsy is an alternative surgical staging method. However, small but significant false negative rates limit its clinical use. The objective of this application is to establish pH threshold sensors to detect occult lymph node metasta...