|Awarded On||February 21, 2018|
|Title||A somatic mutant p53 mouse model of metastatic triple negative breast cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Guillermina Lozano|
Cancers arise from an accumulation of changes to normal cells that allow those cells to grow uncontrollably. To accomplish this feat, most tumor cells disable the function of an important tumor suppressor, p53. When deletion or mutation of p53 occurs, cells no longer listen to internal signals that say ‘stop dividing’. As cells continue to divide, they acquire additional changes that fuel tumor growth. Ultimately, these changes contribute to cells leaving the organ they live in and disseminating to other organs such as the lung, liver, bone and brain, a process called metastasis. The great majority of triple negative breast cancers have lost p53 function and these tumors are the most aggres...