|Awarded On||February 21, 2018|
|Title||PTEN Promotes Diabetic breast cancer metastasis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Chunru Lin|
Diabetic women have an increased risk of developing breast cancer compared to women with normal blood glucose levels; however, the responsible mechanism is not known. We have shown that PTEN, a famous tumor suppressor, is uniquely modified under high glucose conditions. This modification (PTENK27-polyUb) alters its activity, allowing it to dephosphorylate serine/threonine residues, including on proteins Twist1, Snai1 and YAP1, and promoting epithelial mesenchymal transition (EMT). This is significant because EMT has been shown to contribute to metastasis and drug resistance in breast cancer. In human breast cancer tissues, PTENK27-polyUb is elevated in hyperglycemic patients. Also, mice that...