Grant ID RP180248
Awarded On February 21, 2018
Title Characterizing cancer genome instability and translational impact using new sequencing technologies
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Computational Biology
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Ken Chen
Cancer Sites All Sites
Contracted Amount $898,997
Lay Summary

Genome instability is a hallmark of cancer. Cancer cells with homologous recombination deficiency (HRD) often exibit a high level of chromosomal instability containing relatively large numbers of structural variations (SVs). Patients with homologous recombination deficiency (HRD) tumors have been shown to respond to Poly (ADP-ribose) polymerase (PARP) inhibitors. Meanwhile, cancer cells with mismatch-repair (MMR) deficiency often have high mutation (indel) burdens. Patients with MMR deficient tumors (e.g., melanoma and lung cancers) have demonstrated durable clinical responses to cancer immunotherapy such as CTLA-4 or PD-1/PD-L1 blockade. Still, a large fraction of patients were not benefit...

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