|Awarded On||February 21, 2018|
|Title||Functional analyses of linkage-specific ubiquitination in the DNA damage response|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Bin Wang|
|Cancer Sites||All Sites|
Our genetic material (DNA) is continuously damaged from exogenous and endogenous sources leading to DNA lesions. DNA double-strand break (DSB) is one of the most deleterious cellular lesions; one of their harmful effects is that it can promote genome instability, a hallmark of cancer. The cellular responses to DSB involve a sophisticated DNA damage response network that detects, signals, and repairs the lesion; failure of this repair system leads to cancer. Our project aims to decipher the mechanistic details of DSB response in the context of its natural cellular environment, i.e. chromatin in human cells. Ubiquitin (a small molecule that can be attached to a target protein) modification of ...