|Awarded On||February 21, 2018|
|Title||Microwafers as Novel Drug or Gene Delivery Vehicles for Noninvasive Treatment of Retinoblastoma|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Richard Hurwitz|
|Cancer Sites||Eye and Orbit|
We have developed novel, non-invasive microwafers that can deliver nanoparticles (small beads) containing drugs to tissues or tumors. We hypothesize that this system would be ideal for treating retinoblastoma. Retinoblastoma, an ocular cancer that occurs in young children, can affect one or both eyes. Removal of the eye (enucleation) with the tumor is often curative but ophthalmologists are opting for local therapies to control small tumors or systemic chemotherapy to control larger tumors with the goal of saving vision. Sometimes small pieces of tumor break off to form vitreous seeds. There is no good option other than enucleation for this condition. The development of alternative treatment...