|Awarded On||February 21, 2018|
|Title||Understanding TFE3-mediated Tumorigenesis through Analysis of a Novel, Clinically-Relevant Mouse Model of Translocation Renal Cell Carcinoma|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||James Brugarolas|
|Cancer Sites||Kidney and Renal Pelvis|
For reasons that are not well understood, kidney cancer is particularly prevalent in Texas. A most challenging type of kidney cancer is translocation renal cell carcinoma (TRCC). Unlike most kidney cancers, TRCC predominantly affects children and adolescents. Because of its relatively low frequency (compared to adult kidney cancer), TRCC remains understudied and lacks specific therapies. When metastatic, TRCC is uniformly lethal. Here, we propose to deploy the first mouse model of TRCC faithfully reproducing the human disease, which we have already generated, to provide insight into TRCC. This model is based on one of the most common genetic changes in human TRCC (i.e. a particular transloca...