Grant ID RP180147
Awarded On February 21, 2018
Title Prevalence of Rare Passenger Mutations in Biopsy Tissue as Cancer Stratification Markers
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Rice University
Principal Investigator/Program Director David Zhang
Cancer Sites All Sites
Contracted Amount $900,000
Lay Summary

Cancer is caused by acquired mutations in DNA, and different patients' cancer cells and tumors will possess different mutation rates. Only a small proportion of mutations are actually the drive" mutations that cause cancer, and thus far research efforts have focused on understanding and detecting these driver mutations. In contrast, non-pathogenic passenger mutations, considered the incidental by-products of cancer, have received relatively little study as potential markers for cancer diagnostic or prognostic tests. The PI hypothesizes that the prevalence of passenger mutations in a tissue biopsy sample may be correlated with the mutability of a patient's tumor. In other words, pati...

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