Grant ID RP170722
Awarded On August 16, 2017
Title Identification of Critical Dependencies and Actionable Therapeutic Options in Smarcb1-Deficient Pediatric Tumors
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Giulio Draetta
Cancer Sites Gallbladder, Kidney and Renal Pelvis, Liver and Intrahepatic Bile Duct
Contracted Amount $200,000
Lay Summary

Cells have special enzymes that control how genes are expressed. Because of this, even when two people may share the same genes, these enzymes can impact how those genes are expressed and influence physiological processes. Increasingly, we are understanding that these enzymes controlling gene expression may significantly impact the development and progression of cancer. The function of one of these enzymes, Smarcb1, has been documented to be lost in a group of very aggressive pediatric tumors, malignant rhabdoid tumors (MRTs) and renal medullary carcinomas (RMCs). Although very rare, patients with these tumors suffer an overall dismal prognosis, especially very young patients under one year ...

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