Grant ID RP170674
Awarded On August 16, 2017
Title Regulation of Cancer Cell Migration by Secreted Protein Phosphorylation
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Vincent S Tagliabracci
Cancer Sites Breast
Contracted Amount $200,000
Lay Summary

Breast cancer is the second most common malignancy in women and each year in the United States approximately 200,000 new patients are diagnosed with the disease. Thus, there is an urgent need to develop new strategies to tackle this deadly illness. We have discovered that proteins secreted from cancer cells can promote cancer cell migration when chemically modified by a molecule of phosphate in a process termed phosphorylation. The objective of this proposal is to understand the mechanisms by which these secreted phosphoproteins promote cancer cell metastasis. The results from the work described herein may have important implications for patients with breast cancer.