Grant ID RP170671
Awarded On August 16, 2017
Title Targeting a Novel Nuclease PAAN in Triple-Negative Breast Cancer
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Yingfei Wang
Cancer Sites Breast
Contracted Amount $200,000
Lay Summary

MicroRNA is a small non-coding RNA ubiquitously expressed in mammals and controls important physiological and pathological processes. A vast majority of microRNAs are down-regulated in triple-negative breast cancer, leading to tumorigenesis. However, the molecular mechanisms underlying microRNA dysregulation in human triple-negative breast cancer are still elusive. Recently, we identified macrophage migration inhibitory factor as a novel nuclease and named it as PAAN according to its new function. PAAN is highly expressed in primary triple-negative breast tumors. High levels of PAAN in breast tumors are inversely correlated with global down-regulation of microRNAs, but positively correlated ...

Read More