Grant ID RP170660
Awarded On August 16, 2017
Title Optogenetic Toolkit for Precise Epigenome Editing in Cancer Cells
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas A&M University System Health Science Center
Principal Investigator/Program Director Yubin Zhou
Cancer Sites All Sites
Contracted Amount $200,000
Lay Summary

In cancer cells, one frequently observed abnormal signature is aberrant DNA modifications, which lead to uncontrolled cell growth and survival. DNA is composed of 4 building blocks: A, T, G and C. A fraction of C is modified by a methyl group and become methylcytosine (mC). mC can be further modified by proteins belonging to the TET family, which convert mC to further oxidized species and ultimately remove the methyl group in the genome. The level and distribution of mC are disorganized in cancer cells, but the cause and effect relations between those changes and cancer phenotypes is hard to be established, largely owing to the lack of powerful tools to precisely generate or erase mC. To me...

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