|Awarded On||August 16, 2017|
|Title||Optogenetic Toolkit for Precise Epigenome Editing in Cancer Cells|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Yubin Zhou|
|Cancer Sites||All Sites|
In cancer cells, one frequently observed abnormal signature is aberrant DNA modifications, which lead to uncontrolled cell growth and survival. DNA is composed of 4 building blocks: A, T, G and C. A fraction of C is modified by a methyl group and become methylcytosine (mC). mC can be further modified by proteins belonging to the TET family, which convert mC to further oxidized species and ultimately remove the methyl group in the genome. The level and distribution of mC are disorganized in cancer cells, but the cause and effect relations between those changes and cancer phenotypes is hard to be established, largely owing to the lack of powerful tools to precisely generate or erase mC. To me...