Grant ID RP170653
Awarded On August 16, 2017
Title Identify Streptococcus gallolyticus Factors Important for Promoting Colorectal Tumor Development
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas A&M University System Health Science Center
Principal Investigator/Program Director Yi Xu
Cancer Sites Colorectal
Contracted Amount $200,000
Lay Summary

It has been demonstrated that intestinal microbiota influences the development of colorectal cancer (CRC). This microbe-CRC connection suggests a potential paradigm shift in the way CRC is detected, treated and managed. Knowledge of specific microbial components involved in the development of CRC is critical to moving this field forward. Among the bacterial species known to associate with CRC, Streptococcus gallolyticus subsp. gallolyticus (Sg) stands out as having a strong and well-documented clinical association supported by numerous case reports and surveys over the past several decades. We and others further found that Sg is present in a substantial percentage of CRC patients (up to ~ 74...

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