Grant ID RP170633
Awarded On August 16, 2017
Title The Role of the CACNA1D Calcium Channel in Melanoma
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Sean Morrison
Cancer Sites Skin
Contracted Amount $199,828
Lay Summary

Melanoma is responsible for over 80% of deaths from skin cancer. Certain genes are frequently mutated in melanoma cells and cause the cells to proliferate and to metastasize. Drugs that inhibit the functions of these mutant gene products are used to treat patients. These drugs commonly shrink melanoma tumors in patients but within months the melanoma cells develop therapy resistance and disease progression resumes. New therapies are required. We recently discovered that melanoma cells are particularly sensitive to changes in ion gradients. All cells need sodium, potassium, and calcium ion gradients across their membranes to regulate the movement of biologically important molecules throughou...

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