|Awarded On||November 16, 2016|
|Title||Mechanisms of Notch Dysregulation in Pediatric Osteosarcoma|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Brendan Lee|
|Cancer Sites||Bone, Sarcoma|
Osteosarcoma (OS) is the most common primary bone cancer and occurs in adolescents and young adults. Among diagnosed OS patients, 15-20% present with lung metastasis at initial diagnosis and about 40% develop metastasis at a later stage. Current treatments including surgery and chemotherapy have increased survival rate to around 70%. However, the clinical outcome for metastatic OS remains poor. Our knowledge of the genetic causes of OS and mechanisms of OS progression and metastasis are still limited. Interestingly, we have shown that mice with chronically activated Notch1 (GOF) in bone cells develop spontaneous OS with a high level of genomic instability, which is a signature feature of hu...