|Awarded On||November 16, 2016|
|Title||Optimizing Chemoradiation Strategies by Tumor Metabolism Interrogation|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Stephen Lai|
|Cancer Sites||Head and Neck, Thyroid|
Despite continued improvements in chemotherapy and radiation regimens, we remain unable to adapt treatment protocols to actual tumor response, which leads to unnecessary treatment toxicity and suboptimal clinical effectiveness. We propose assessment of tumor metabolism to improve chemotherapy and radiation effectiveness. These treatments release free radicals (reactive oxygen species (ROS)), which when left unchecked, kill tumor cells. Tumors protect themselves by using metabolically generated free radical scavengers. Treatment-induced changes in metabolic activity can be measured biochemically. By analogy, treatment-induced ROS can be compared to a fast ship generating a wake in the water....