|Awarded On||August 16, 2017|
|Title||Chemically based disruption of oncogenic beta-catenin activity in liver tissue|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Hao Zhu|
|Cancer Sites||Gallbladder, Liver and Intrahepatic Bile Duct|
A significant percentage of cancers of the liver and the colon are caused by genetic mutations that compromise the same cell-to-cell communication process that normally ensures the orderly regeneration of cells in each organ. Despite our understanding of the root causes for these cancers, the management of these diseases nevertheless relies on drugs that are not specifically tailored for these mutations thus frequently incurring unwanted toxicities and eliciting unpredictable mechanisms of drug resistance. ur study will directly test the ability of two novel classes of chemicals that emerged from a large chemical screening effort to identify agents that could counteract the cell growth-prom...