Grant ID RP170180
Awarded On August 16, 2017
Title Mechanistic Roles of Long Non-Coding RNA in Glioblastoma Development and Treatment
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Suyun Huang
Cancer Sites Brain and Other Nervous System
Contracted Amount $823,500
Lay Summary

Glioblastomas (GBMs) are the most common and fatal brain tumors. Glioblastomas are largely refractory to surgical therapy, radiotherapy, chemotherapy, and adjuvant therapy. Consequently, the prognosis for patients with glioblastoma is very poor. Texas has the second highest rate of death from brain tumor in the US. Little is known about the mechanisms underlying oncogenesis of glioblastoma. Studies outlined in this proposal will test the biology functions of EGFR induced long non-coding RNAs (lncRNAs) and underlying mechanisms in glioblastoma development and progression. The lncRNAs are long RNAs which do not encode proteins. lncRNAs have been strongly implicated in cell fate decisions and i...

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