|Awarded On||August 16, 2017|
|Title||Mechanistic Roles of Long Non-Coding RNA in Glioblastoma Development and Treatment|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Suyun Huang|
|Cancer Sites||Brain and Other Nervous System|
Glioblastomas (GBMs) are the most common and fatal brain tumors. Glioblastomas are largely refractory to surgical therapy, radiotherapy, chemotherapy, and adjuvant therapy. Consequently, the prognosis for patients with glioblastoma is very poor. Texas has the second highest rate of death from brain tumor in the US. Little is known about the mechanisms underlying oncogenesis of glioblastoma. Studies outlined in this proposal will test the biology functions of EGFR induced long non-coding RNAs (lncRNAs) and underlying mechanisms in glioblastoma development and progression. The lncRNAs are long RNAs which do not encode proteins. lncRNAs have been strongly implicated in cell fate decisions and i...