|Awarded On||November 16, 2016|
|Title||Prediction of nuclear export signals in proteins|
|Award Mechanism||Individual Investigator Research Awards for Computational Biology|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Nick Grishin|
|Cancer Sites||All Sites|
The goal is to efficiently find proteins that are being carried out of the nucleus of a cell into its cytoplasm (i.e. "exported") by an exporter protein called CRM1. We will develop a computer program that, taking a protein sequence as input, predicts if this protein is exported by CRM1. This program will evaluate the energy of binding between candidate cargo protein and CRM1. The major challenge is to design a mathematical formula to compute this energy accurately. To devise the formula, we will use amino acid sequences of known cargo proteins and 3D structures of complexes between CRM1 and its cargos. The values of parameters in the formula will be optimized to distinguish betwee...