Grant ID RP170170
Awarded On November 16, 2016
Title Prediction of nuclear export signals in proteins
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Computational Biology
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Nick Grishin
Cancer Sites All Sites
Contracted Amount $844,989
Lay Summary

The goal is to efficiently find proteins that are being carried out of the nucleus of a cell into its cytoplasm (i.e. "exported") by an exporter protein called CRM1. We will develop a computer program that, taking a protein sequence as input, predicts if this protein is exported by CRM1. This program will evaluate the energy of binding between candidate cargo protein and CRM1. The major challenge is to design a mathematical formula to compute this energy accurately. To devise the formula, we will use amino acid sequences of known cargo proteins and 3D structures of complexes between CRM1 and its cargos. The values of parameters in the formula will be optimized to distinguish betwee...

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