|Awarded On||November 16, 2016|
|Title||B cell receptor signaling intersects with angiogenesis in diffuse large B cell lymphoma|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Ricardo Aguiar|
|Cancer Sites||Leukemia, Lymphoma|
Angiogenesis, the development of new vessels to support tumor grown, is a cancer hallmark. In diffuse large B cell lymphoma (DLBCL), a common and aggressive cancer type, angiogenesis is associated with poor outcome. However, we know little about the contribution of the lymphoma cell to this abnormal vessel development, and clinical trials that tested classical anti-angiogenic agents in DLBCL were negative. Thus, a better understanding of the proangiogenic role of the lymphoma cell will facilitate the development of new treatment strategies that target the tumor and its supporting microenvironment. DLBCL is also driven by constitutive activation of B cell receptor (BCR) signals. Earlier, we...