|Awarded On||November 16, 2016|
|Title||Mechanisms of melanoma metastasis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Sean Morrison|
Most cancer deaths are caused by distant metastasis, in which cancer cells spread throughout the body. Cancers that do not metastasize are almost always curable because they can be surgically removed. Yet little is known about the molecular mechanisms that allow cancer cells to spread through the blood to other parts of the body. Distant metastasis is known to be a very inefficient process in which most cancer cells that enter the blood die before they are able to form distant metastases, but it has not been understood why. We recently discovered that the metastasis of human melanoma cells is limited by oxidative stress, caused by the generation of highly reactive molecules, called reactive...