|Awarded On||August 16, 2017|
|Title||Tumor suppression, p53 and retrotransposons|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||John M Abrams|
|Cancer Sites||All Sites|
The p53 gene is mutated in a majority of human cancers. Collectively, these alterations represent the most common genetic change shared across the spectrum of tumors seen in patients. p53 belongs to a class of tumor suppressor genes that restrict tissue growth, but a definitive molecular explanation for how this gene prevents tumors still eludes us. To better understand actions of p53 that, when disabled, permit cancer formation we built a sophisticated genetic platform that enables functional interrogation of p53 variants seen in the clinic. From this we discovered that core functions of p53 are coupled to ancient factors that restrain mobile elements called retrotransposons (unlike most ...