Grant ID RP170071
Awarded On November 16, 2016
Title Genetic Epidemiology and Molecular Basis of Cancer Predisposition in Pediatric Rhabdomyosarcoma
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Prevention and Early Detection
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Philip Lupo
Cancer Sites Sarcoma
Contracted Amount $1,488,105
Lay Summary

Compared to other pediatric cancers, the outlook for children with rhabdomyosarcoma (RMS) remains poor. In particular, for those with high-risk disease, fewer than 43% of patients survive for more than 5 years. Currently, there are no genetic testing and counseling strategies for children with RMS; there are no clinical surveillance or prevention protocols; and there are few therapeutic targets for this highly fatal tumor. One of the strongest risk factors for RMS is having a genetic cancer predisposition syndrome. While it is believed that about 7% of RMS patients have changes (or mutations) in the genes responsible for these syndromes, there have been: 1) no population-based assessments t...

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