Grant ID RP160770
Awarded On May 18, 2016
Title Optical opening of blood-brain barrier for brain tumor drug delivery by plasmonic nanobubbles
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Zhenpeng Qin
Cancer Sites Brain and Other Nervous System
Contracted Amount $200,000
Lay Summary

Brain tumors are known to be lethal, with a median survival of 14.6 months for glioblastoma multiforme. A major and unique obstacle for brain tumor drug delivery is the presence of blood-brain barrier. The blood brain barrier is a sophisticated structure that gives an optimal environment for brain function but also severely limits the penetration of anti-cancer drugs. The goal of our project is to develop a novel approach to optically open the blood-brain barrier thus allowing the access of a wide range of therapeutic drugs to brain tumor cells. Specifically, we will design and synthesize plasmonic nanomaterials to target the tight junction proteins, a critical component of the blood-brain b...

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