Grant ID RP160739
Awarded On May 18, 2016
Title Targeting Histone Acetylation Readers in MLL-translocated Leukemias
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Xiaobing Shi
Cancer Sites Leukemia
Contracted Amount $200,000
Lay Summary

Leukemias are cancers of the bone marrow and blood, mostly while blood cells. In children, leukemias are the most common cancers that account for almost 1 out of 3 cancers. The most prevalent childhood leukemia types are acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Despite remarkable improvement in the treatment outcomes over the past decades, a high-risk subgroup of ALL patients that bear translocations involving the MLL (mixed-lineage leukemia) gene are particularly associated with poor response to standard treatments and dismal prognosis. Rearrangements of the MLL gene account for about 80% of infant ALL and up to 50% of infant AML. In leukemias, MLL is found to fu...

Read More