Grant ID RP160713
Awarded On May 18, 2016
Title Amino Acid Sensing: Directing Cell Growth through mTORC1
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jenna L Jewell
Cancer Sites All Sites
Contracted Amount $198,983
Lay Summary

Growth is an essential process whereby cells and organisms accumulate mass and increase in size. Cells grow by responding to environmental cues that trigger signaling pathways to regulate growth. When these signaling pathways are constitutively turned on, the cell grows uncontrollably leading to cancer. One signaling pathway implicated in cancer is the mTORC1 pathway. In fact, mTORC1 is often referred to as the “master regulator” of cell growth. The mTORC1 pathway is constitutively active in many human cancers, and therapeutics like rapamycin that target and block the mTORC1 pathway, have shown promise in cancer patients in several clinical trials. Currently there are two rapamycin analogs, ...

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