Grant ID RP160622
Awarded On November 19, 2015
Title Computational live cell histology
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Computational Biology
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Gaudenz Danuser
Cancer Sites Skin
Contracted Amount $392,779
Lay Summary

We rapidly gain genomic information of cancers, but tumors from different patients and even from different cells of the same tumor can exhibit vast genetic differences. This applies especially to melanoma, a deadly form of skin cancer, where diagnosis and definition of a robust treatment strategy based on the genomic profile is impossible. At the level of cells, however, heterogeneous genomic profiles seem to invoke universal programs to invade, survive and colonize distant organs. This supports the hypothesis that diverse oncogenic backgrounds converge to a few key functions that confer metastatic efficiency. Quantitative live cell histology is designed to identify cellular behaviors that a...

Read More