|Awarded On||November 19, 2015|
|Title||Arylhydrocarbon receptor mediated modulation of colorectal cancer by microbiota metabolites|
|Award Mechanism||Individual Investigator Research Awards for Prevention and Early Detection|
|Institution/Organization||Texas Agrilife Research|
|Principal Investigator/Program Director||Robert S Chapkin|
This proposal seeks to determine how bacteria present in the human gastrointestinal tract modulate colon cancer in a high fat diet environment. It is becoming increasingly clear that the intestinal bacterial community plays an important role in human health. Alterations in the bacterial community composition and function have been correlated to several diseases including cancer, insulin resistance and diabetes, and autism. However, very few studies have accounted for the role of the intestinal bacteria - specifically, the molecules that it produces due to metabolism - in cancer prevention and treatment. Since studies have shown that (i) body mass index is strongly associated with risk of col...