|Awarded On||November 19, 2015|
|Title||Exosomal DNA as a surrogate biomarker for early diagnosis and therapeutic stratification in pancreatic cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Anirban Maitra|
Pancreatic cancer has one of the lowest 5-year survival rates amongst solid tumors. Early detection of pancreatic cancer at a surgically resectable stage has a profound impact on prognosis. However current blood-based tests for pancreatic cancer lack the sensitivity or specificity for identifying individuals who are most at risk for harboring this malignancy. Cancer cells release tiny messengers called “exosomes” into the blood circulation, and do so in significantly more voluminous quantities than normal tissues. Exosomes contain considerable genetic information representative of the tumor cells from which they are released, including the DNA abnormalities (mutations) that are present i...