|Awarded On||November 19, 2015|
|Title||Integrin-mediated IL-18 signaling in the prevention and treatment of inflammation-associated colorectal cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Peter Dube|
Worldwide colorectal cancer is the third and fourth most common cancer-related cause of death for women and men respectively. There are many factors that contribute colorectal cancer but uncontrolled inflammation is a major risk factor. This partially explains why people with inflammatory bowel disease, IBD, are at a significantly higher risk of developing colorectal cancer. A significant advance in our understanding of the link between IBD and colorectal cancer was made a few years ago when it was discovered that a set of genes that regulate inflammation through a cellular machine called the inflammasome, could protect against both IBD and colorectal cancer. The inflammasome leads to the pr...