Grant ID RP160512
Awarded On November 19, 2015
Title Integrin-mediated IL-18 signaling in the prevention and treatment of inflammation-associated colorectal cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Peter Dube
Cancer Sites Colorectal
Contracted Amount $859,620
Lay Summary

Worldwide colorectal cancer is the third and fourth most common cancer-related cause of death for women and men respectively. There are many factors that contribute colorectal cancer but uncontrolled inflammation is a major risk factor. This partially explains why people with inflammatory bowel disease, IBD, are at a significantly higher risk of developing colorectal cancer. A significant advance in our understanding of the link between IBD and colorectal cancer was made a few years ago when it was discovered that a set of genes that regulate inflammation through a cellular machine called the inflammasome, could protect against both IBD and colorectal cancer. The inflammasome leads to the pr...

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