|Awarded On||November 19, 2015|
|Title||Amplified gold nanoparticle-mediated radiosensitization of tumors|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Sunil Krishnan|
|Cancer Sites||Head and Neck|
Sequestering gold nanoparticles (GNPs) within tumors has gained prominence in recent years as a means to escalate radiation therapy (RT) dose to the tumor & improve the curability of locally advanced tumors. Current methods require large quantities of gold (clinically unachievable without direct injection into the tumor), low energy kilovolt x-rays (not used in the clinic for over half a century), immediate RT after GNP administration (since the gold is rapidly cleared by the kidneys & only remains in the tumor vasculature for a couple of minutes after intravenous administration), & re-administration of GNPs before each RT fraction (increasing cost and toxicity) – clinical translation is hi...