Grant ID RP160497
Awarded On November 19, 2015
Title Amplified gold nanoparticle-mediated radiosensitization of tumors
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Sunil Krishnan
Cancer Sites Head and Neck
Contracted Amount $899,309
Lay Summary

Sequestering gold nanoparticles (GNPs) within tumors has gained prominence in recent years as a means to escalate radiation therapy (RT) dose to the tumor & improve the curability of locally advanced tumors. Current methods require large quantities of gold (clinically unachievable without direct injection into the tumor), low energy kilovolt x-rays (not used in the clinic for over half a century), immediate RT after GNP administration (since the gold is rapidly cleared by the kidneys & only remains in the tumor vasculature for a couple of minutes after intravenous administration), & re-administration of GNPs before each RT fraction (increasing cost and toxicity) – clinical translation is hi...

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