Grant ID RP160493
Awarded On November 19, 2015
Title Characterization and pharmacological targeting of the oncogenic activity of Jumonji enzymes
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Elisabeth Martinez
Cancer Sites All Sites
Contracted Amount $899,997
Lay Summary

We have discovered and characterized a new inhibitor of a set of enzymes that are over-expressed in many cancers and in drug-resistant and radiation resistant tumors and which drive their aberrant growth, the Jumonji histone demethylases. The compound has potent and selective anti-cancer activity in cancer cells and in animal models but does not affect normal cells. In this application, we will determine how the drug specifically inhibits cancer, will identify its main cellular targets and will explore its use as a potential sensitizer for radiation therapy and for chemo-resistant cancers, laying the foundation for future clinical applications.