|Awarded On||November 19, 2015|
|Title||Cytokine signaling in Ewing sarcoma|
|Award Mechanism||Individual Investigator Research Awards for Cancer in Children and Adolescents|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Yuzuru Shiio|
|Cancer Sites||Bone, Sarcoma|
Cells in our body are communicating with each other using a group of proteins called cytokines. Likewise, cancer cells communicate among themselves and with normal cells in patient’s body using cytokines. Although important roles played by cytokines are well established in a variety of adult cancers, little is known about the roles of cytokines in children’s cancers. We discovered a new and unconventional type of cytokine signaling in Ewing sarcoma, a cancer of bone and soft tissue in children and young adults. Our data show that Ewing sarcoma is uniquely dependent on this cytokine signaling: Blocking this cytokine signaling profoundly inhibited proliferation and tumorigenicity of Ewing sarc...