Grant ID RP160462
Awarded On November 19, 2015
Title Systematic identification of small molecule inhibitors that manipulate telomerase activities
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Zhou Songyang
Cancer Sites All Sites
Contracted Amount $898,288
Lay Summary

The telomerase consists of the TERT enzyme and the TERC RNA template. Telomerase expression and activity are up-regulated in cancer cells, and telomerase dysregulation has been linked to poor prognosis and drug resistance. These studies indicate that the telomerase is an attractive target for anti-cancer therapies. Telomerase inhibition should specifically target tumor cells and work in a broad spectrum of cancers. Treating cancer cells with telomerase inhibitors, however, can provoke cells to adopt telomerase-independent mechanisms, leading to drug resistance. Here, we propose strategies that target regulatory pathways of the telomerase, not the telomerase itself. Specifically, we will targ...

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