|Awarded On||November 19, 2015|
|Title||Protein Truncation Mutations in WIP1: Effects on Cancer and Hematopoiesis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Lawrence A Donehower|
|Cancer Sites||Leukemia, Lymphoma, Sarcoma|
The single most frequent deleterious event that occurs in human cancer may be disruption of function in a protein called p53. A major function of p53 is to protect the normal cell from various types of damage and stress and assist in repairing the cell damage. One protective function of p53 is to protect the normal cell from evolving into a cancer cell. Most human cancers evolve through altering p53 in a way that it no longer functions in its usual protective way. Some cancer-targeted therapies are being developed that attempt to restore or enhance p53 function in a cancer cell that has lost it. In so doing, the therapy-induced p53 will actually induce death of the cancer cell. Our lab...