|Awarded On||November 19, 2015|
|Title||The role of the Lats kinases in sarcomatoid renal cell carcinoma|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Thomas J Carroll|
|Cancer Sites||Bladder, Kidney and Renal Pelvis, Lung and Bronchus|
Renal cell carcinoma (RCC) is the most common type of kidney cancer. Scientific advances over the last several years have given us with a better understanding of this disease and provided us with a number of therapeutic options. However, one type of RCC, known as sarcomatoid RCC or sRCC, has evaded our understanding. sRCC is extremely fast growing and frequently spreads to other tissues. It is usually resistant to all types of treatment and patients diagnosed with sRCC usually do not survive a year. Based on DNA sequence data from human patients, we mutated two genes (Lats1 and 2) in the kidneys of mice. Amazingly, this resulted in sRCC formation with metastasis to the lungs. We found that t...